An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

Abstract Background Exosome mediated mRNA delivery is a promising strategy for the treatment of multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation. In this study, we boosted exosome production via simultaneously reducing the expression of genes inhibiting...

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Detalhes bibliográficos

Principais autores:	Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan, Guodong Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-10-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Exosomes Yield mRNA cargo Red cell membrane Familial hypercholesterolemia
Acesso em linha:	https://doi.org/10.1186/s12951-022-01668-3
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