The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment

Abstract Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity. The transcriptomics-based CRC classification identified a cluster of patients with epithelial-mesenchymal transition (EMT), the a...

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Main Authors: Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wiener
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2025-10-01
Sraith:Cell Communication and Signaling
Ábhair:
Colorectal cancer
Collagen
Organoid
Consensus molecular subtype
Notch
5-HT
Rochtain Ar Líne:https://doi.org/10.1186/s12964-025-02395-6
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