Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T cells

The success of chimeric antigen receptor (CAR) T cell therapies in refractory hematologic malignancies has prompted investigation of their efficacy in solid tumors. AUTO6NG is a dual-transduced GD2-targeting CAR that encodes distinct modules designed to enhance T cell activity in relapsed/refractory...

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Bibliografiske detaljer

Principais autores:	Wei Wang, Muhammad Al-Hajj, Alireza S. Alavi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2023-09-01
Serier:	Molecular Therapy: Methods & Clinical Development
Fag:	droplet digital PCR vector copy number chimeric antigen receptor T cells genetically engineered T cells immunotherapy cell therapy
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2329050123001055
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