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pH-responsive virus-drug conjugates for targeted PD-L1 silencing and enhanced cancer immunotherapy

Abstract Clinical efficacy of virotherapy is often limited by poor transduction and off-target effects. To overcome these hurdles, we engineered a multi-stage, pH-responsive virus-drug conjugate (VDC) for targeted, cancer immunotherapy. Our VDC comprises a recombinant adeno-associated virus serotype...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: S.-Ja Tseng, Ivan M. Kempson, Yi-Cheng Ho, Pan-Chyr Yang, Zi-Xian Liao
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2026-03-01
Rangatū:Journal of Nanobiotechnology
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s12951-026-04347-9
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