Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

BackgroundAggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death. Although CDT could be an important virulence factor, it is unclear how it enters the nucleus to exert its cytotoxicity.ObjectiveT...

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Principais autores:	Siriyod Denmongkholchai, Prashant Katare, Sarocha Choochuay, Panida Thanyasrisung, Keiko Tsuruda, Motoyuki Sugai, Skorn Mongkolsuk, Oranart Matangkasombut
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-04-01
Series:	Frontiers in Microbiology
Assuntos:	Aggregatibacter actinomycetemcomitans bacterial genotoxin cytolethal distending toxin cytotoxicity host factors Saccharomyces cerevisiae
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fmicb.2019.00890/full
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