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Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action study

Background Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. The levonorgestrel-releasing intrauterine system is an effective long-term treatment but is discontinued by many due to unpredictable bleeding, or adverse effects. The selective progesterone recepto...

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Principais autores: Lucy HR Whitaker, Lee J Middleton, Lee Priest, Smita Odedra, Versha Cheed, Elaine P Nicholls, Alistair RW Williams, Neil Roberts, Clive E Stubbs, Konstantios Tryposkiadis, Hannah Bensoussane, Rohan Chodankar, Alison A Murray, Moira Nicol, Aleksandra O Tsolova, Kaiming Yin, Marcos Cruz, Hui Wei Leow, Lucy E Kershaw, Suzanne L McLenachan, Graham McKillop, Jane Walker, Scott I Semple, T Justin Clark, Mary Ann Lumsden, Dharani K Hapangama, Lucky Saraswat, Siladitya Bhattacharya, Paul Smith, Jane Daniels, Hilary OD Critchley
Formato: Artigo
Idioma:Inglês
Publicado em: NIHR Journals Library 2023-10-01
coleção:Efficacy and Mechanism Evaluation
Assuntos:
heavy menstrual bleeding
ulipristal acetate
selective progesterone receptor modulator
levonorgestrel releasing intrauterine system
randomised controlled trial
fibroid
leiomyoma
adenomyosis
endometrium
uterus
quality of life
amenorrhoea
ultrasound
progesterone receptor modulator endometrial associated changes
drug-induced liver injury
immunohistochemistry
dynamic contrast-enhanced magnetic resonance imaging
stereology
urgent safety measures
patient and public involvement
Acesso em linha:https://doi.org/10.3310/FGLQ1687
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