Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Secreted proteins in the bone marrow microenvironment play critical roles in acute myeloid leukemia (AML). Through an ex vivo functional screen of 94 cytokines, we identified that the pro-inflammatory cytokine interleukin-1 (IL-1) elicited profound expansion of myeloid progenitors in ∼67% of AML pat...

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Hlavní autoři:	Alyssa Carey, David K. Edwards, V, Christopher A. Eide, Laura Newell, Elie Traer, Bruno C. Medeiros, Daniel A. Pollyea, Michael W. Deininger, Robert H. Collins, Jeffrey W. Tyner, Brian J. Druker, Grover C. Bagby, Shannon K. McWeeney, Anupriya Agarwal
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2017-03-01
Edice:	Cell Reports
Témata:	bone marrow microenvironment AML interleukin-1 p38MAPK IL1R1 functional screening
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124717303352
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