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IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening

Since most preclinical drug permeability assays across the blood-brain barrier (BBB) are still evaluated in rodents, we compared an in vitro mouse primary endothelial cell model to the mouse b.End3 and the acellular parallel artificial membrane permeability assay (PAMPA) models for drug screening pu...

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Autori principali: Ina Puscas, Florian Bernard-Patrzynski, Martin Jutras, Marc-André Lécuyer, Lyne Bourbonnière, Alexandre Prat, Grégoire Leclair, V. Gaëlle Roullin
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2019-11-01
Serie:Pharmaceutics
Soggetti:
mouse brain microvascular endothelial cells
primary cell culture
bend.3 cell line
ivivc
blood-brain barrier
Accesso online:https://www.mdpi.com/1999-4923/11/11/587
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