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Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

Abstract Background Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we inve...

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Principais autores: Olga Rafikova, Anup Srivastava, Ankit A. Desai, Ruslan Rafikov, Stevan P. Tofovic
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-04-01
Serier:Respiratory Research
Fag:
Pulmonary hypertension
Glycolytic switch
Mitochondrial complexes
Protein nitration
Metabolomics
Online adgang:http://link.springer.com/article/10.1186/s12931-018-0776-1
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