NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors

Abstract Although immune checkpoint inhibitors (ICIs) have elicited desirable clinical outcomes, their effective application remains an obstacle due to immunologically “cold” tumors that manifest lymphocyte exhaustion or poor infiltration. Hence, exploring new therapeutic strategies to enhance antit...

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Autores principales:	Ying Gao, Lin Zuo, Yu Zheng, Keyan Sun, Yunhui Gao, Xiaobo Xu, Zengqiang Li, Daiying Zuo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-05-01
Colección:	Breast Cancer Research
Materias:	Immune checkpoint inhibitors Immunogenicity NOTCH1 Cellular senescence
Acceso en línea:	https://doi.org/10.1186/s13058-025-02045-2
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