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IL11 activates the placental inflammasome to drive preeclampsia

IntroductionPreeclampsia is a life-threatening disorder of pregnancy unique to humans. Interleukin (IL)11 is elevated in serum from pregnancies that subsequently develop early-onset preeclampsia and pharmacological elevation of IL11 in pregnant mice causes the development of early-onset preeclampsia...

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Autors principals: Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell, Evdokia Dimitriadis
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-05-01
Col·lecció:Frontiers in Immunology
Matèries:
interleukin 11
preeclampsia
ASC
NLRP3
inflammasome
hypertension
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1175926/full
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