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Mitochondrial dysfunction in sepsis-associated acute kidney injury: mechanisms and therapeutic potential

Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication in critically ill adult patients, accounting for nearly 50% of acute kidney injury (AKI) cases in intensive care units and carrying a mortality rate exceeding 40%. Its pathogenesis extends beyond traditional concepts o...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Chong Wang, Qi Liu, He Wang, Qian Zhang, Boxin Yang, Hongchao Liu, Zhongxin Li, Zhongjun Shen, Jingjin Tao, Zhen Xu, Yuying Nie, Xiangyi Xu, Huike Guo, Shuo Yang, Liyan Cui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2026-05-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
apoptosis
ferroptosis
immunometabolism
metabolic reprogramming
mitochondrial dysfunction
oxidative stress
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1829288/full
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