PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Abstract Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA damage has been described as the for...

Полное описание

Библиографические подробности

Главные авторы:	Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Hongshan Zhang, Michael L Nosella, Morgan Dasovich, T Reid Alderson, Anthony K L Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Springer Nature 2024-11-01
Серии:	EMBO Reports
Предметы:	PARP1 ADP-Ribosylation Phase Separation Biomolecular Condensates DNA Repair
Online-ссылка:	https://doi.org/10.1038/s44319-024-00285-5
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