Effect of Tryptic Digestion on Sensitivity and Specificity in MALDI-TOF-Based Molecular Diagnostics through Machine Learning

The digestion of protein into peptide fragments reduces the size and complexity of protein molecules. Peptide fragments can be analyzed with higher sensitivity (often > 10² fold) and resolution using MALDI-TOF mass spectrometers, leading to improved pattern recognition by common machine l...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sumon Sarkar, Abigail Squire, Hanin Diab, Md. Kaisar Rahman, Angela Perdomo, Babafela Awosile, Alexandra Calle, Jonathan Thompson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-09-01
Schriftenreihe:	Sensors
Schlagworte:	machine learning molecular diagnostics precision medicine biomarker MALDI-TOF diagnostic
Online-Zugang:	https://www.mdpi.com/1424-8220/23/19/8042
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