A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates

Summary: The emergence of SARS-CoV-2 variants raises concerns about the efficacy of existing COVID-19 vaccines and therapeutics. Previously, we identified a conserved cryptic class 5 epitope of SARS-CoV-2 receptor binding domain (RBD) by two cross-neutralizing antibodies 7D6 and 6D6. Intriguingly, t...

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Autori principali:	Lingyan Cui, Tingting Li, Miaolin Lan, Ming Zhou, Wenhui Xue, Sibo Zhang, Hong Wang, Minqing Hong, Yali Zhang, Lunzhi Yuan, Hui Sun, Jianghui Ye, Qingbing Zheng, Yi Guan, Ying Gu, Ningshao Xia, Shaowei Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-07-01
Serie:	iScience
Soggetti:	Virology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004224014330
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A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates

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