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Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

ABSTRACT Sepsis‐associated lung injury (SALI) remains a critical clinical challenge, partly driven by ferroptosis‐induced endothelial dysfunction. The pathological interaction between FUN14 domain‐containing protein 1 (FUNDC1) and glutathione peroxidase 4 (GPX4) promotes ferroptosis and disrupts mit...

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Principais autores: Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-04-01
Serier:Advanced Science
Fag:
endothelial cells
ferroptosis
lung injury
mitophagy
sepsis
Online adgang:https://doi.org/10.1002/advs.202516488
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