Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

BackgroundMethotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after treatment with MTX. We have investigated cell-type specific DNA methylation changes across the genome in naïve and memory CD4+ T cells before and af...

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Egile Nagusiak:	Kari Guderud, Line H. Sunde, Siri T. Flåm, Marthe T. Mæhlen, Maria D. Mjaavatten, Ellen S. Norli, Ida M. Evenrød, Bettina K. Andreassen, Sören Franzenburg, Andre Franke, Simon Rayner, Kristina Gervin, Benedicte A. Lie
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2021-11-01
Saila:	Frontiers in Immunology
Gaiak:	Rheumatoid arthritis T cells CD4 memory CD4 naïve DNA methylation RRBS
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.713611/full
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