Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

Hydroxymethylation is a simple chemical reaction, in which the introduction of the hydroxymethyl group can lead to physical–chemical property changes and offer several therapeutic advantages, contributing to the improved biological activity of drugs. There are many examples in the literature of the...

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Principais autores:	Soraya S. Santos, Rodrigo V. Gonzaga, Cauê B. Scarim, Jeanine Giarolla, Marina C. Primi, Chung M. Chin, Elizabeth I. Ferreira
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2022-02-01
סדרה:	Frontiers in Chemistry
נושאים:	hydroxymethylation hydroxymethyl compounds hydroxymethyl drug prodrug design hydroxymethylnitrofurazone
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fchem.2021.734983/full
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