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Regulation of Nrf2/Keap1 signalling in human skeletal muscle during exercise to exhaustion in normoxia, severe acute hypoxia and post-exercise ischaemia: Influence of metabolite accumulation and oxygenation

The Nrf2 transcription factor is induced by reactive oxygen and nitrogen species and is necessary for the adaptive response to exercise in mice. It remains unknown whether Nrf2 signalling is activated by exercise in human skeletal muscle. Here we show that Nrf2 signalling is activated by exercise to...

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Principais autores: Angel Gallego-Selles, Marcos Martin-Rincon, Miriam Martinez-Canton, Mario Perez-Valera, Saúl Martín-Rodríguez, Miriam Gelabert-Rebato, Alfredo Santana, David Morales-Alamo, Cecilia Dorado, Jose A.L. Calbet
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-09-01
coleção:Redox Biology
Assuntos:
Fatigue
Performance
Ischaemia
AMPK
CaMKII
High-intensity exercise
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231720308326
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