Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Takashi Murakami, Michiaki Unno, Robert M. Hoffman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2019-05-01
Schriftenreihe:	Cells
Schlagworte:	recombinant methioninase methionine dependence nude mice orthotopic implantation patient-derived tumor
Online-Zugang:	https://www.mdpi.com/2073-4409/8/5/410
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!