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JUNB O‐GlcNAcylation‐Mediated Promoter Accessibility of Metabolic Genes Modulates Distinct Epithelial Lineage in Pulmonary Fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is a lethal disease with substantial unmet medical needs. While aberrant epithelial remodeling is a key factor in IPF progression, the molecular mechanisms behind this process remain elusive. Harnessing a 3D patient‐derived organoid model and multi‐omics...

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Principais autores: Marie‐Therese Bammert, Meshal Ansari, Leoni Haag, Zuhdi Ahmad, Victoria Schröder, Joseph Birch, Diana Santacruz, Werner Rust, Coralie Viollet, Benjamin Strobel, Alec Dick, Florian Gantner, Holger Schlüter, Fidel Ramirez, Muriel Lizé, Matthew J. Thomas, Huy Q. Le
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-02-01
Serier:Advanced Science
Fag:
aberrant epithelial remodeling
bronchiolization
JUNB
O‐GlcNAcylation
pulmonary fibrosis
Online adgang:https://doi.org/10.1002/advs.202406751
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