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Identification of cholinergic centro-cingulate topography as main contributor to cognitive functioning in Parkinson’s disease: Results from a data-driven approach

BackgroundDegeneration of the cholinergic system plays an important role in cognitive impairment in Parkinson’s disease (PD). Positron emission tomography (PET) imaging using the presynaptic vesicular acetylcholine transporter (VAChT) tracer [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) allows for re...

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Principais autores: Sygrid van der Zee, Prabesh Kanel, Martijn L. T. M. Müller, Teus van Laar, Nicolaas I. Bohnen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-10-01
Serier:Frontiers in Aging Neuroscience
Fag:
Parkinson’s disease
cognition
acetylcholine
PET
neuroimaging
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1006567/full
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