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Insights on Aggregation of Hen Egg-White Lysozyme from Raman Spectroscopy and MD Simulations

Protein misfolding and aggregation play a significant role in several neurodegenerative diseases. In the present work, the spontaneous aggregation of hen egg-white lysozyme (HEWL) in an alkaline pH 12.2 at an ambient temperature was studied to obtain molecular insights. The time-dependent changes in...

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Principais autores: Divya Chalapathi, Amrendra Kumar, Pratik Behera, Shijulal Nelson Sathi, Rajaram Swaminathan, Chandrabhas Narayana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-10-01
Colecção:Molecules
Assuntos:
protein aggregation
Raman spectroscopy
molecular dynamics
protein–protein interactions
structural biology
Acesso em linha:https://www.mdpi.com/1420-3049/27/20/7122
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