Tissue and peripheral T cell receptor repertoire predicts immunotherapy response and progression-free survival in NSCLC patients

Abstract Immunotherapy has opened new avenues of treatment for patients with advanced non-small cell lung cancer (NSCLC) without previous hope of survival. Unfortunately, only a small percentage of patients benefit from it and there is not an effective biomarker to predict patients’ response. Since...

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Autors principals:	Manuel Pino-González, Martín Lázaro-Quintela, Irene Alonso-Álvarez, María Gallardo-Gómez, Laura Juaneda-Magdalena, Alejandro Francisco-Fernández, Silvia Calabuig-Fariñas, Eloisa Jantus-Lewintre, Mónica Martínez-Fernández
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Scientific Reports
Matèries:	Non-small cell lung cancer Pembrolizumab Predictive biomarker Immunotherapy response T cell receptor TCR repertoire
Accés en línia:	https://doi.org/10.1038/s41598-025-21612-3
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