GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane attachment influence PrPC-associated signaling, and...

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Detalhes bibliográficos

Principais autores:	Berta Puig, Hermann C Altmeppen, Luise Linsenmeier, Karima Chakroun, Florian Wegwitz, Ulrike K Piontek, Jörg Tatzelt, Clive Bate, Tim Magnus, Markus Glatzel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2019-01-01
coleção:	PLoS Pathogens
Acesso em linha:	https://doi.org/10.1371/journal.ppat.1007520
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