Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures

Abstract Background Charge heterogeneity is one of the most critical quality attributes of antibodies, which has strong influence on drug’s biological activity and safety. Finding out the key components that affecting charge variants is of great significance for establishing a competitive culture pr...

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Hauptverfasser:	Huijie Niu, Jiaqi Wang, Mengjuan Liu, Miaomiao Chai, Liang Zhao, Xuping Liu, Li Fan, Wen-Song Tan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SpringerOpen 2018-09-01
Schriftenreihe:	Bioresources and Bioprocessing
Schlagworte:	Charge heterogeneity Chinese hamster ovary cells Medium components Monoclonal antibody Uridine
Online-Zugang:	http://link.springer.com/article/10.1186/s40643-018-0228-2
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