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Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

Dietary fatty acids are the main building blocks for cell membranes in animals, and mechanisms must therefore exist that compensate for dietary variations. We isolated C. elegans mutants that improved tolerance to dietary saturated fat in a sensitized genetic background, including eight alleles of t...

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Main Authors: Mario Ruiz, Rakesh Bodhicharla, Emma Svensk, Ranjan Devkota, Kiran Busayavalasa, Henrik Palmgren, Marcus Ståhlman, Jan Boren, Marc Pilon
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
membrane fluidity
phospholipid
lipotoxicity
fluorescence recovery after photobleaching
forward genetics
membrane homeostasis
Online Access:https://elifesciences.org/articles/40686
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