Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location

Abstract Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of the midline harboring the same canonical mutation at the Lysine 27 of the histones H3 tail. Two hundred and...

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Detalhes bibliográficos

Principais autores:	David Castel, Cathy Philippe, Thomas Kergrohen, Martin Sill, Jane Merlevede, Emilie Barret, Stéphanie Puget, Christian Sainte-Rose, Christof M. Kramm, Chris Jones, Pascale Varlet, Stefan M. Pfister, Jacques Grill, David T. W. Jones, Marie-Anne Debily
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-11-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Pediatric high-grade glioma Diffuse midline glioma H3 K27M-mutant Diffuse intrinsic pontine glioma Epigenetics DNA methylation profiling
Acesso em linha:	http://link.springer.com/article/10.1186/s40478-018-0614-1
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