P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats

Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expression is increased in kidney disease and blockade/...

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Main Authors:	Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2024-04-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-024-59635-x
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