Low Responsiveness of Macroencapsulated Human Islets Towards Glucose Challenge Despite Excellent Survival in Silicone-Based Oxygen-Delivering Devices

Islet encapsulation has the potential to enable transplantation without requirement for life-long immunosuppression. The period between implantation and revascularisation is most harmful for encapsulated islets as they receive nutrients and oxygen exclusively via diffusion. This critical time gap mu...

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Autori principali:	Daniel Brandhorst, Heide Brandhorst, Daniel A. Domingo-Lopez, Eoin O’Cearbhaill, Fergal B. Coulter, Rebecca Spiers, Stefano Deotti, Helena M. Kelly, Garry P. Duffy, Paul R. V. Johnson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-12-01
Serie:	Bioengineering
Soggetti:	cell culture cell therapy encapsulation devices humans hypoxia inflammation
Accesso online:	https://www.mdpi.com/2306-5354/13/1/56
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