Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals.

Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are unknown, but persistent meiotic DNA damage and asynapsis may be triggers. Here we investigate the contribution of these lesions to oocyte el...

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Главные авторы:	Jeffrey M Cloutier, Shantha K Mahadevaiah, Elias ElInati, André Nussenzweig, Attila Tóth, James M A Turner
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2015-10-01
Серии:	PLoS Genetics
Online-ссылка:	https://doi.org/10.1371/journal.pgen.1005462
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