Interpretable deep learning framework for mapping E3–substrate binding interfaces
Abstract E3 ubiquitin ligases recognize substrates through specific interfaces. Accurate delineation of these interfaces is essential, as mutations disrupting them impair protein ubiquitination and drive cancer progression. However, available E3–substrate interface data are sparse and systematic pre...
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| Váldodahkkit: | , , , , , , , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
Nature Portfolio
2026-05-01
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| Ráidu: | Nature Communications |
| Liŋkkat: | https://doi.org/10.1038/s41467-026-73143-8 |
| Fáddágilkorat: |
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