Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models

Abstract We previously developed human CAR macrophages (CAR-M) and demonstrated redirection of macrophage anti-tumor function leading to tumor control in immunodeficient xenograft models. Here, we develop clinically relevant fully immunocompetent syngeneic models to evaluate the potential for CAR-M...

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Autori principali:	Stefano Pierini, Rashid Gabbasov, Maria Cecilia Oliveira-Nunes, Rehman Qureshi, Alison Worth, Shuo Huang, Karan Nagar, Crystal Griffin, Lurong Lian, Yumi Yashiro-Ohtani, Kayleigh Ross, Christopher Sloas, Michael Ball, Benjamin Schott, Poonam Sonawane, Linara Cornell, Daniel Blumenthal, Sotheavy Chhum, Nicholas Minutolo, Kerri Ciccaglione, Lauren Shaw, Isaac Zentner, Hyam Levitsky, Olga Shestova, Saar Gill, Bindu Varghese, Daniel Cushing, Sabrina Ceeraz DeLong, Sascha Abramson, Thomas Condamine, Michael Klichinsky
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-01-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-55770-1
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