Stereoelectronic and hydrogen-bonding effects on hydroxyproline conformation
Abstract Collagen’s structural integrity and biological function derive from its characteristic triple helix, governed by a unique amino acid sequence containing the rare residue (2S,4R)-hydroxyproline (4R-Hyp). Substituting 4R-Hyp with its diastereomer 4S-Hyp markedly reduces triple-helix thermal s...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2026-03-01
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| coleção: | Communications Chemistry |
| Acesso em linha: | https://doi.org/10.1038/s42004-026-01984-x |
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