Hopf bifurcations in an atypical p53 protein oscillator model with discrete delay or distributed delay

Human cells have a natural cancerous defense system, and p53 protein is at the core. It is well known that p53 relies on oscillatory dynamic behavior to perform tumor suppressor functions. However, the mechanism of its oscillation remains unclear. To reveal the effect of time lag on the onset of p53...

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Autores principales:	Nan Liu, Hongli Yang, Liangui Yang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-01-01
Colección:	Results in Physics
Materias:	p53 oscillator model Hopf bifurcation Functional differential equation Local or non-local delay Normalization and central manifold methods Anti-cancer strategy
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S221137972301077X
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