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Application of spatial transcriptomics analysis using the Visium system for the mouse nasal cavity after intranasal vaccination

Intranasal vaccines that elicit mucosal immunity are deemed effective against respiratory tract infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but their ability to induce humoral immunity characterized by immunoglobulin A (IgA) and IgG production is low. It has been...

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Main Authors: Sakiko Toyama, Tomoko Honda, Sadahiro Iwabuchi, Shinichi Hashimoto, Kenzaburo Yamaji, Yuko Tokunaga, Yusuke Matsumoto, Hideya Kawaji, Takashi Miyazaki, Yoshiaki Kikkawa, Michinori Kohara
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
carboxyvinyl polymer (CVP)
intranasal vaccine
nasal passage (NP)
spatial transcriptomics
Visium
microfold (M) cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209945/full
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