A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to leiomyomas, renal cysts, and cancers, though the r...

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Detalhes bibliográficos

Principais autores:	Julie Adam, Ming Yang, Christina Bauerschmidt, Mitsuhiro Kitagawa, Linda O’Flaherty, Pratheesh Maheswaran, Gizem Özkan, Natasha Sahgal, Dilair Baban, Keiko Kato, Kaori Saito, Keiko Iino, Kaori Igarashi, Michael Stratford, Christopher Pugh, Daniel A. Tennant, Christian Ludwig, Benjamin Davies, Peter J. Ratcliffe, Mona El-Bahrawy, Houman Ashrafian, Tomoyoshi Soga, Patrick J. Pollard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2013-05-01
coleção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124713001733
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