Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming

BackgroundTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) characterized by a high risk of metastasis and poor prognosis. Current chemotherapy-based treatments are often limited by systemic toxicity and drug resistance. Brusatol (BRU), a natural compound with repor...

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Autors principals:	Xuan Yu, Xueling Diao, Xiaokai Fan, Chuantao Wu, Siyuan Wang, Maoxuan Liu, Edwin Cheung, Liang Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-02-01
Col·lecció:	Frontiers in Oncology
Matèries:	breast cancer Brusatol metabolic reprogramming natural compound pentose phosphate pathway
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1708878/full
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