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Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis

Hyperactivation of sterol regulatory element binding protein 1c (SREBP‐1c), which transcriptionally induces expression of enzymes responsible for de novo lipogenesis and triglyceride (TG) formation, is implicated in nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) pathoge...

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Principais autores: Wojciech Swiatek, K. Mark Parnell, G. Allen Nickols, Bruce F. Scharschmidt, Jared Rutter
Format: Artigo
Jezik:Inglês
Izdano: Wolters Kluwer Health/LWW 2020-05-01
Serija:Hepatology Communications
Online dostop:https://doi.org/10.1002/hep4.1498
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