Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes

Edaravone (EDA), an antioxidant drug approved for the treatment of ischemic stroke and amyotrophic lateral sclerosis, was recently proposed as a remyelinating candidate for the treatment of multiple sclerosis. Here, we synthesized twelve EDA analogues <b>2b</b>–<b>4c</b> showing three substitution p...

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Detalhes bibliográficos

Principais autores:	Eleonora Colombo, Stefania Olla, Cristina Minnelli, Alessia Formato, Caterina Veroni, Silvia Corbisiero, Mattia Pericolo, Chiara Siguri, Giovanna Mobbili, Cristina Agresti, Pierfausto Seneci
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-10-01
coleção:	Molecules
Assuntos:	edaravone amyotrophic lateral sclerosis prodrugs mechanism of action chemical probes antioxidant activity
Acesso em linha:	https://www.mdpi.com/1420-3049/28/19/6928
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