Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor. To identify new genes involved in the cellular uptake of LDL, we develop...

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Detalhes bibliográficos

Principais autores:	Diego Lucero, Ozan Dikilitas, Michael M. Mendelson, Zahra Aligabi, Promotto Islam, Edward B. Neufeld, Aruna T. Bansal, Lita A. Freeman, Boris Vaisman, Jingrong Tang, Christian A. Combs, Yuesheng Li, Szilard Voros, Iftikhar J. Kullo, Alan T. Remaley
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-01-01
coleção:	Journal of Lipid Research
Assuntos:	transgelin LDL LDL receptor endocytosis whole-genome CRISPR-Cas9 screen cellular LDL uptake
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227521001437
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