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Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements that are necessary for synapsis and crossing ov...

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Principais autores: Manickam Gurusaran, Jelle J. Biemans, Christopher W. Wood, Owen R. Davies
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-06-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
LINC complex
nuclear envelope
SUN1
KASH5
X-ray crystallography
molecular dynamics
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2023.1144277/full
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