Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix contains high amounts of Aggrecan and COMP, we hypothes...

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Hlavní autoři:	Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-08-01
Edice:	Frontiers in Bioengineering and Biotechnology
Témata:	chondrocyte hypertrophy endochondral ossification COMP aggrecan periosteum periosteal chondrogenesis
On-line přístup:	https://www.frontiersin.org/article/10.3389/fbioe.2020.01036/full
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