Acute bioenergetic insulin sensitivity of skeletal muscle cells: ATP-demand-provoked glycolysis contributes to stimulation of ATP supply

Skeletal muscle takes up glucose in an insulin-sensitive manner and is thus important for the maintenance of blood glucose homeostasis. Insulin resistance during development of type 2 diabetes is associated with decreased ATP synthesis, but the causality of this association is controversial. In this...

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Principais autores:	Rosie A. Donnell, Jane E. Carré, Charles Affourtit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-07-01
coleção:	Biochemistry and Biophysics Reports
Assuntos:	Skeletal muscle insulin resistance Cellular energy metabolism Efficiency of mitochondrial ATP synthesis ATP demand Oxidative phosphorylation Type 2 diabetes
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405580822000747
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