Deep learning-based differential diagnosis of major depression and bipolar disorder using microglia-cellular sensors and patient-derived small extracellular vesicles

Abstract The diagnosis of major depressive disorder (MDD) and bipolar disorder (BD) relies on symptom-based evaluations. Both MDD as well as BD present episodes of depressed mood, often leading to misdiagnosis and treatment delays. Our study presents a novel deep learning–based diagnostic approach t...

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Autori principali:	Jorge Zambrano, Alejandro Luarte, Julian Contreras, Juan P. Perez, Liliana Yantén-Fuentes, Miguel Prieto, Pablo Lazcano, Ursula Wyneken, Claudio A. Perez
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-04-01
Serie:	Scientific Reports
Soggetti:	Biomarkers convolutional neural networks deep learning extracellular vesicles mood disorders diagnosis major depressive disorder
Accesso online:	https://doi.org/10.1038/s41598-026-47476-9
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