N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase

Breakdown of neuro-glial N-acetyl-aspartate (NAA) metabolism results in the failure of developmental myelination, manifest in the congenital pediatric leukodystrophy Canavan disease caused by mutations to the sole NAA catabolizing enzyme aspartoacylase. Canavan disease is a major point of focus for...

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Hlavní autoři:	Jeremy S. Francis, PhD, Ireneusz Wojtas, PhD, Vladimir Markov, MD, Steven J. Gray, PhD, Thomas J. McCown, PhD, R. Jude Samulski, PhD, Larissa T. Bilaniuk, MD, Dah-Jyuu Wang, PhD, Darryl C. De Vivo, MD, Christopher G. Janson, MD, Paola Leone, PhD
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2016-12-01
Edice:	Neurobiology of Disease
Témata:	N-acetylaspartate Aspartoacylase Canavan disease Myelination Energy
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996116302340
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