Exploring the neuroprotective role of artesunate in mouse models of anti-NMDAR encephalitis: insights from molecular mechanisms and transmission electron microscopy

Abstract Background The pathway involving PTEN-induced putative kinase 1 (PINK1) and PARKIN plays a crucial role in mitophagy, a process activated by artesunate (ART). We propose that patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis exhibit insufficient mitophagy, and ART enhanc...

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Prif Awduron:	Jingsi Liu, Yingyi Huang, Tinglin Qian, Jinyu Chen, Yuewen Ding, Zhaohui Lai, Xinghua Zhong, Mingjun Lai, Huili Zhang, Yuanyuan Wang, Honghao Wang, Yu Peng
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2024-05-01
Cyfres:	Cell Communication and Signaling
Pynciau:	anti-NMDAR encephalitis Mitophagy PINK1/PARKIN pathway Artesunate
Mynediad Ar-lein:	https://doi.org/10.1186/s12964-024-01652-4
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