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Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9.

Nsp9 is a conserved accessory component of the coronaviral replication and transcription complex. It is the predominant substrate of nsp12's nucleotidylation activity while also serving to recruit proteins required for viral 5'-capping. Anti-nsp9 specific nanobodies have been isolated previously. We...

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書誌詳細
主要な著者: Yue Pan, Indu R Chandrashekaran, Luke Tennant, Jamie Rossjohn, Dene R Littler
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2023-01-01
シリーズ:PLoS ONE
オンライン・アクセス:https://doi.org/10.1371/journal.pone.0283194
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