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Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex

Background REST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits Na+/Ca2+exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on brain promoter (Br) after stroke. We identified a new putative RE1 site in Ncx1 heart promoter (Ht) sequence (Ht‐RE1) that partic...

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Principais autores: Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-03-01
Serier:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fag:
DNA methylation
DNMT1
MeCP2
NCX1
REST
stroke
Online adgang:https://www.ahajournals.org/doi/10.1161/JAHA.123.030460
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