The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis

PM2.5 is a key environmental pollutant that induces inflammatory lung injury.Effective prevention and treatment for PM2.5-induced lung damage remain lacking.This study investigated MCC950′s protective role in PM2.5-exposed mice and macrophages.PM2.5 triggers NLRP3/Caspase-1-mediated pyroptosis, ampl...

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Үндсэн зохиолчид:	Zhuoxiao Han, Ying Han, Ranran Li, Kexin Fan, Xiao Zhang, Tengfei Sun, Yue Li, Hua Qiao
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2026-01-01
Цуврал:	Current Research in Toxicology
Нөхцлүүд:	MCC950 PM2.5 Pyroptosis NLRP3 Alveolar macrophage
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2666027X26000034
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!